Urine pH and Diabetes

Urine pH and Diabetes

DISEASE	SUMMARY	JOURNAL PUBLISHED / LINK
Diabetes	(1)    Low urine pH is an independent, practical predictor  or marker of type 2 diabetes. (2)    Low urinary pH has a close association with insulin resistance. (3)    Studied 3119 subjects over 5 years: Groups: UpH = 5.0, 5.5, 6, >=6.5	Diabetic Research and Clinical Practice, Vol 130, pp 9-14, 2017 Y. Hashimoto et al, Japan, 3119 patients, citations 25, Kyoto Univ., Japan Urinary pHis a predictor of Diabetes
Diabetes	(1) Lower urine pH was associated with higher serum urea nitrogen which reflects high intake of protein-rich diet, whereas it had no relation to serum creatinine. (2)    The purpose of this study was to investigate the relationship of urine acidification with visceral obesity and the metabolic syndrome. (3)    1,051 male subjects recruited excluding subjects who were treated for hypertension, dyslipidemia, diabetes mellitus, and hyperuricemia and had the past history of chronic liver disease, chronic kidney disease and cancer, were excluded in this study. All subjects were administered to urine pH, blood and physical examinations. Lower urine pH was associated with higher serum urea nitrogen which reflects high intake of protein-rich diet, whereas it had no relation to serum creatinine. (4)    Lower urine pH was also associated with an increase in waist circumference, homeostasis model assessment-R, fasting plasma glucose, HbA1c, serum triglyceride, serum uric acid and with a decrease in high density lipoprotein cholesterol. (5)    Urine pH was not associated with mean blood pressure. Urine acidification is a characteristic of visceral obesity and the metabolic syndrome. (6)    High intake of protein-rich diet may contribute urine acidification, which is associated with various metabolic abnormalities in visceral obesity.	Endocrine Journal, 2011, 58(5), 363-367 Michio Otsuki et al , 1051 patients, 63 Citations, Osaka Univ, Japan Association of urine acidification with visceral obesity and the metabolic syndrome